m-Chloroperbenzoic acid → 4-(2-Fluoro-4-nitrophenoxy)-6-(methylsulfinyl)thieno[3,2-d]pyrimidine

HRID 1711054노트

반응식

HRID 1711054 반응식
[F:1][C:2]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:3]=1[O:4][C:5]1[C:6]2[S:13][C:12]([S:14][CH3:15])=[CH:11][C:7]=2[N:8]=[CH:9][N:10]=1.C1C=C(Cl)C=C(C(OO)=[O:31])C=1>C(Cl)Cl>[F:1][C:2]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:3]=1[O:4][C:5]1[C:6]2[S:13][C:12]([S:14]([CH3:15])=[O:31])=[CH:11][C:7]=2[N:8]=[CH:9][N:10]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 594244784-(2-Fluoro-4-nitrophenoxy)-6-(methylthio)thieno[3,2-d]pyrimidine

생성물 1

HCID 594245544-(2-Fluoro-4-nitrophenoxy)-6-(methylsulfinyl)thieno[3,2-d]pyrimidine수율 101.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 281 (1.1 g, 3.2 mmol) and m-CPBA (77%, 890 mg, 12.8 mmol) in DCM at 0° C. was stirred for 2 hours, diluted with DCM, washed with ice water, NaHCO3 solution and water again; dried and concentrated to give the title compound 284 (1.15 g, quantitative) as a yellowish solid. MS (m/z): 354.0 (M+H) (found).

후처리

  1. washwashed with ice water, NaHCO3 solution and water again
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-04b14e37e17e4bab9f4f63b2aa8e1d56
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790729B2

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