2-(4-Nitro-phenyl)-ethanesulfonic acid tert-butylamide → 2-(4-Amino-phenyl)-ethanesulfonic acid tert-butylamide

HRID 1711289노트

반응식

HRID 1711289 반응식
[C:1]([NH:5][S:6]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([NH:5][S:6]([CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 685055592-(4-Nitro-phenyl)-ethanesulfonic acid tert-butylamide

생성물 1

HCID 685049012-(4-Amino-phenyl)-ethanesulfonic acid tert-butylamide수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-(4-Nitro-phenyl)-ethanesulfonic acid tert-butylamide (as prepared in the step above, 633 mg, 2.21 mmol) was hydrogenated under balloon pressure in EtOH (20 mL) using 10% Pd/C (100 mg) for 12 h. The reaction mixture was filtered through Celite and concentrated to obtain 2-(4-amino-phenyl)-ethanesulfonic acid tert-butylamide (536 mg, 95%) which was used directly without further purification.

후처리

  1. customfor 12 h
  2. filtrationThe reaction mixture was filtered through Celite
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5077d8a82268484e893dd356757dc5c4
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790724B2

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