Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 4-Amino-N-(1,1-dimethylethyl)benzenesulfonamide | HCID 832627 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide | HCID 54850284 | 53.1% |
반응 단계
To a solution of 4-amino-N-tert-butyl-benzenesulfonamide (J. Med. Chem. (2003), 46(16), 3463-3475, 228 mg, 1.00 mmol) in DCM (10 mL), NBS (178 mg, 1.00 mmol) was added. The resulting mixture was stirred at RT for 30 min and washed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL). The organic layer was separated, dried and concentrated to obtain 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide (163 mg, 53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07790724B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-82168f1fbbe246799a59bd1f0f3f1298 |
| 출처 메모 | uspto-grants-2010_09 |