2,4-Dichloropyridine → 4-(2-Chloropyridin-4-yloxy)-2-fluorobenzenamine

HRID 1711631노트

반응식

HRID 1711631 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[F:9][C:10]1[CH:11]=[C:12]([OH:17])[CH:13]=[CH:14][C:15]=1[NH2:16]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:17][C:12]2[CH:13]=[CH:14][C:15]([NH2:16])=[C:10]([F:9])[CH:11]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 335152,4-DichloropyridineHCID 27359194-Amino-3-fluorophenol

생성물 1

HCID 594583014-(2-Chloropyridin-4-yloxy)-2-fluorobenzenamine수율 86%

실험 절차

Using a procedure analogous to Example A2, 2,4-dichloropyridine (8.0 g, 54 mmol) and 3-fluoro-4-aminophenol (8.0 g, 62.9 mmol) were combined to provide 4-(2-chloro-pyridin-4-yloxy)-2-fluorophenylamine (11g, 86% yield). 1H NMR (300 MHz, DMSO-d6) δ 8.24 (d, J=5.7 Hz, 1H), 7.00 (dd, J=9.0, 2.7 Hz, 1H), 6.89-6.73 (m, 4H), 5.21 (br s, 2H); MS (ESI) m/z: 239.2 (M+H+).

출처 및 근거

ORD 기록
ord-94b87c3d47b0418082d8670f0ccf3bd1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790756B2

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