4-(4-methoxyphenoxy)piperidine → HCID 58673073, 화합물

HRID 1711732노트

반응식

HRID 1711732 반응식
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:32]=[CH:31][C:23]([O:24][CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:22][CH:21]=1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:28]1[CH2:27][CH2:26][CH:25]([O:24][C:23]2[CH:31]=[CH:32][C:20]([O:19][CH3:18])=[CH:21][CH:22]=2)[CH2:30][CH2:29]1)=[O:9])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 34092334-(4-methoxyphenoxy)piperidineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

생성물 1

HCID 58673073HCID 58673073, 화합물수율 73%

실험 절차

Prepared in analogy to Example 1 from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 4-(4-methoxy-phenoxy)-piperidine. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 73%). MS (m/e): 448.2 (M+H+, 100%).

후처리

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

출처 및 근거

ORD 기록
ord-1236d25cd38b477aa055859f2b8171b4
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790763B2

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