Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 7-Iodo-3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-Iodosuccinimide | HCID 120273 | — |
| 반응물 | 3-(4-Phenoxyphenyl)thieno[3,2-c]pyridin-4-amine | HCID 18450763 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Iodo-3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine | HCID 18450878 | 70% |
반응 단계
A solution of Example 10A (1.69 g, 5.3 mmol) in DMF (20 mL) was treated with NIS (1.26 g, 5.6 mmol), stirred at room temperature for 3 hours, poured into water, and filtered. The filter cake was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes to provide 1.64 g (70% yield) of the desired product. MS (ESI(+)) m/e 444.8 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737160B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4913f3f3dcaf4671a8270d6e845f5975 |
| 출처 메모 | uspto-grants-2010_06 |