4-Bromopyridine-3-carbaldehyde → 1-(4-Bromo-pyridin-3-yl)-2-methyl-propan-1-ol

HRID 1712072노트

반응식

HRID 1712072 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH:8]=[O:9].[CH:10]([Mg]Br)([CH3:12])[CH3:11]>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH:8]([OH:9])[CH:10]([CH3:12])[CH3:11]

참가 물질

4

반응물 2

HCID 111167404-Bromopyridine-3-carbaldehydeHCID 178418365HCID 178418365, 화합물

생성물 1

HCID 592051921-(4-Bromo-pyridin-3-yl)-2-methyl-propan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 4-bromo-pyridine-3-carbaldehyde (400 mg, 2.15 mmol) in THF (10 mL) at −78° C. was added dropwise 1.0 M isopropyl-magnesium bromide solution in THF (3.23 mL). After 15 min, the reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate, then purification by flash chromatography eluted with 50% ethyl acetate in hexane to yield 1-(4-bromo-pyridin-3-yl)-2-methyl-propan-1-ol as slight yellow crystals.

후처리

  1. customthe reaction was quenched with saturated ammonium chloride solution
  2. extractionextracted with ethyl acetate
  3. custompurification by flash chromatography
  4. washeluted with 50% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-db9281c220384cdb9385a95dea3da23b
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790895B2

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