1,2,4,5-Tetrafluorobenzene → (2,3,5,6-Tetrafluorophenyl)methanamine

HRID 1712213

반응식

HRID 1712213 반응식
FC1C(F)=CC(F)=C(F)C=1.[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[C:14]#[N:15].C(C1(C(F)=C(F)C=C(F)C1F)C=O)#N>>[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[CH2:14][NH2:15]

참가 물질

4

반응물 3

HCID 94741,2,4,5-TetrafluorobenzeneHCID 2975462,3,5,6-TetrafluorobenzonitrileHCID 866412531-Cyano-2,3,5,6-tetrafluorobenzaldehyde

생성물 1

HCID 53849533(2,3,5,6-Tetrafluorophenyl)methanamine

실험 절차

From the toluene extract, a small amount of a sample was withdrawn, and it was subjected to GC analysis. As a result of the analysis, the tetrafluoroterephthalonitrile as a raw material remained in an amount of 21.0 mol %, and tetrafluoroterephthalaldehyde was obtained in an amount of only 5.0 mol %. The amount of 2,3,5,6-tetrafluorobenzene was 0.65 mol %, the amount of 2,3,5,6-tetrafluorobenzonitrile was 0.53 mol %, and 1-cyano-2,3,5,6-tetrafluorobenzaldehyde wherein a nitrile group on only one side had reacted was obtained in an amount of 63.1 mol %. On the other hand, the aqueous phase was neutralized and then subjected to GC analysis. As a result of the analysis, presence of 2.88 mol % of 2,3,5,6-tetrafluorobenzylamine was confirmed. The results are set forth in Table 2.

후처리

  1. customhad reacted
  2. customwas obtained in an amount of 63.1 mol %

출처 및 근거

ORD 기록
ord-a2182f04859f47cc8405c398b13ed95a
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790931B2

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