Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Hydroxy-5-methylbenzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Fluorosalicylic acid | HCID 67661 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 생성물 | 2-Hydroxy-5-methylbenzyl alcohol | HCID 257452 | — |
반응 단계
A solution of 4.80 g of 4-fluoro-2-hydroxybenzoic acid in 100 ml of tetrahydrofuran is added dropwise at 0° C. to the suspension of 5.29 g of lithium aluminium hydride in 150 ml of tetrahydrofuran and stirred over 2 hours. The reaction mixture is admixed dropwise successively with 6 ml of water, 6 ml of 15% NaOH and 24 ml of water, and stirred over 1 hour. The mixture is filtered and the filtrate is concentrated by evaporation. The crude title compound is obtained as a red-orange oil from the residue. Rf=0.20 (1:1 EtOAc-heptane); Rt=2.47.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07790715B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-965226e7585f417aa694817c400d0aa6 |
| 출처 메모 | uspto-grants-2010_09 |