Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate

HRID 1712650노트

반응식

HRID 1712650 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][NH:12][CH2:11]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 10583745tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate

생성물 1

HCID 685001703-(Hydroxymethyl)azetidine trifluoroacetate

실험 절차

Trifluoroacetic acid (0.413 ml) was added to tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) with cooling in an ice bath, followed by stirring at the same temperature for 30 minutes. Then the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to give a crude product of the title compound (209.8 mg) as a yellow oil.

후처리

  1. temperaturewith cooling in an ice bath
  2. stirringThen the reaction mixture was stirred at room temperature for 1.5 hours
  3. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-a3848cf7b5da400ea19765646c790181
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790885B2

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