Potassium Carbonate → 4-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-butyronitrile

HRID 1713044

반응식

HRID 1713044 반응식
C([O:3][C:4]([C:6]1[NH:10][C:9]2[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)[O:13][C:8]=2[CH:7]=1)=O)C.C(OC(=O)C(CC)CCN1C(=S)N2C3C=C(C4C=CC([N+]([O-])=O)=CC=4)OC=3C=C2C1=O)C.[N:55]([CH2:58][CH2:59][CH2:60][C:61]#[N:62])=[C:56]=[S:57].C([O-])([O-])=O.[K+].[K+]>C(O)C>[N+:20]([C:17]1[CH:16]=[CH:15][C:14]([C:12]2[O:13][C:8]3[CH:7]=[C:6]4[C:4](=[O:3])[N:55]([CH2:58][CH2:59][CH2:60][C:61]#[N:62])[C:56](=[S:57])[N:10]4[C:9]=3[CH:11]=2)=[CH:19][CH:18]=1)([O-:22])=[O:21]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 151346444-Isothiocyanato-butyronitrileHCID 594634452-(4-nitro-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl esterHCID 86618327HCID 86618327, 화합물

생성물 1

HCID 116537784-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-butyronitrile

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
110 °C

실험 절차

2-(4-nitro-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (60.97 mg, 0.21 mmol), prepared as described hereinabove (see, preparation of Compound 1), 4-isothiocyanato-butyronitrile (664 mg, 2.1 mmol) and a fine powder of anhydrous K2CO3 (27.6 mg, 0.2 mmol) are mixed together in a sealed tube, provided with a magnetic stirrer, and the mixture is heated at 110° C. for 2 hours. The mixture is cooled to room temperature, ethanol is added (2 ml), and the formed precipitate is filtered. The crude product is recrystallized from ethanol to give Compound 35.

후처리

  1. customprovided with a magnetic stirrer
  2. temperatureThe mixture is cooled to room temperature
  3. filtrationthe formed precipitate is filtered
  4. customThe crude product is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f7bf6337c3444f61a0f6334556d517b1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795255B2

연결된 노트

불러오는 중…