6-Amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione → 5,6-diamino-1-ethyl-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1713183노트

반응식

HRID 1713183 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[N:5]([CH2:11][CH2:12][CH3:13])[C:4](=[O:14])[C:3]=1[N:15]=O>CO.[Pd]>[NH2:15][C:3]1[C:4](=[O:14])[N:5]([CH2:11][CH2:12][CH3:13])[C:6](=[O:10])[N:7]([CH2:8][CH3:9])[C:2]=1[NH2:1]

참가 물질

4

반응물 1

HCID 219163746-Amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione

생성물 1

HCID 219163965,6-diamino-1-ethyl-3-propylpyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 6-amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione (300 mg) in methanol (10 ml) was added 10% palladium on carbon catalyst (50 mg), and the mixture was hydrogenated under hydrogen at 30 psi for 2 hours. The mixture was filtered through celite, and solvent was removed from the filtrate under reduced pressure, to provide 5,6-diamino-1-ethyl-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (2).

후처리

  1. filtrationThe mixture was filtered through celite, and solvent
  2. customwas removed from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-a1bbfd8b10d5481fb695dd56f0bc3fd3
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795268B2

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