6-Amino-3-propylpyrimidine-2,4(1H,3H)-dione → 6-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1713185노트

반응식

HRID 1713185 반응식
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[CH:3]=1.[N:13]([O-])=[O:14].[Na+]>C(O)(=O)C.O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=[O:14]

참가 물질

4

반응물 2

HCID 110302506-Amino-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 23668193Sodium Nitrite

생성물 1

HCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 21899381Acetic acid--water (1/1)용매

반응 조건

온도
70 °C

실험 절차

To a solution of 6-amino-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.6 g) in a mixture of 50% acetic acid/water (160 ml) at 70° C. was added sodium nitrite (4.5 g) in portions over a period of 15 minutes. The mixture was stirred at 70° C. for 45 minutes, then the reaction mixture concentrated to a low volume under reduced pressure. The solid was filtered off, and washed with water, to provide 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (11).

후처리

  1. concentrationthe reaction mixture concentrated to a low volume under reduced pressure
  2. filtrationThe solid was filtered off
  3. washwashed with water

출처 및 근거

ORD 기록
ord-5b402bf9790044e8828db401fc990756
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795268B2

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