Triethylamine → 8-(4-Bromobenzylamino)adenosine

HRID 1713259노트

반응식

HRID 1713259 반응식
Br[C:2]1[N:3]([C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=2[N:19]=1)[C@@H:4]1[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]1[OH:6].Cl.[Br:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1.C(N(CC)CC)C>C(O)C>[Br:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:2]2[N:3]([C:13]3[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=3[N:19]=2)[C@@H:4]2[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]2[OH:6])=[CH:25][CH:24]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 965448-BromoadenosineHCID 27240964-Bromobenzylamine hydrochloride

생성물 1

HCID 674555318-(4-Bromobenzylamino)adenosine수율 90.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 8-bromoadenosine (0.100 g), 4-bromobenzylamine hydrochloride (0.193 g) and triethylamine (0.201 mL) in ethanol (2.9 mL) was stirred under reflux for 96 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1) to give the title compound (0.118 g).

후처리

  1. temperatureunder reflux for 96 hours
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1)

출처 및 근거

ORD 기록
ord-639b01dafef94996920f61aa46db08fb
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795236B2

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