8-(3'-Benzyloxybiphenyl-4-ylmethyl-amino)-2',3',5'-tris-o-(tert-butyldimethylsilyl)adenosine → 2',3',5'-Tris-o-(tert-butyl-dimethylsilyl)-8-(3'-hydroxybiphenyl-4-ylmethylamino)-adenosine
반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23]3[N:24]([C:55]4[N:56]=[CH:57][N:58]=[C:59]([NH2:62])[C:60]=4[N:61]=3)[C@@H:25]3[O:54][C@H:44]([CH2:45][O:46][Si:47]([C:50]([CH3:53])([CH3:52])[CH3:51])([CH3:49])[CH3:48])[C@@H:35]([O:36][Si:37]([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38])[C@H:26]3[O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[Si:28]([O:27][C@@H:26]1[C@H:35]([O:36][Si:37]([C:40]([CH3:41])([CH3:42])[CH3:43])([CH3:39])[CH3:38])[C@@H:44]([CH2:45][O:46][Si:47]([C:50]([CH3:51])([CH3:52])[CH3:53])([CH3:48])[CH3:49])[O:54][C@H:25]1[N:24]1[C:55]2[N:56]=[CH:57][N:58]=[C:59]([NH2:62])[C:60]=2[N:61]=[C:23]1[NH:22][CH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=2)=[CH:20][CH:19]=1)([C:31]([CH3:33])([CH3:34])[CH3:32])([CH3:29])[CH3:30]참가 물질
4
실험 절차
A mixture of 8-(3′-benzyloxybiphenyl-4-ylmethyl-amino)-2′,3′,5′-tris-O-(tert-butyldimethylsilyl)adenosine (0.713 g) and 10% palladium on carbon (55.4 wt % H2O, 0.480 g) in ethyl acetate (11 mL) was stirred at room temperature for 23 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure to give the title compound (0.615 g).
후처리
- filtrationThe insoluble material was filtered out
- concentrationthe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-9e156b14a62b4cb8859616c7f441519c
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07795236B2
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