8-(3'-Benzyloxybiphenyl-4-ylmethylamino)adenosine → 8-(3'-Hydroxybiphenyl-4-ylmethylamino)adenosine

HRID 1713327노트

반응식

HRID 1713327 반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23]3[N:24]([C:34]4[N:35]=[CH:36][N:37]=[C:38]([NH2:41])[C:39]=4[N:40]=3)[C@@H:25]3[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[C@H:26]3[OH:27])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23]3[N:24]([C:34]4[N:35]=[CH:36][N:37]=[C:38]([NH2:41])[C:39]=4[N:40]=3)[C@@H:25]3[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[C@H:26]3[OH:27])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 594603638-(3'-Benzyloxybiphenyl-4-ylmethylamino)adenosine

생성물 1

HCID 594604808-(3'-Hydroxybiphenyl-4-ylmethylamino)adenosine수율 93.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 8-(3′-benzyloxybiphenyl-4-ylmethyl-amino)adenosine (0.103 g) and 10% palladium on carbon (55.4 wt % H2O, 0.047 g) in methanol (7.4 mL) was stirred at room temperature for 17.5 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=8/1 to 6/1) to give the title compound (0.081 g).

후처리

  1. filtrationThe insoluble material was filtered out
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=8/1 to 6/1)

출처 및 근거

ORD 기록
ord-23317bac68204da2add70d1d0e5779c5
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795236B2

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