Water → 1-(3-Bromomethyl 4-hydroxybutyl)-1H-pyrimidine-2,4-dione

HRID 1713377노트

반응식

HRID 1713377 반응식
[Br:1][CH2:2][CH:3]([CH2:14][O:15]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:4][CH2:5][N:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][C:7]1=[O:13].CC1C=CC(S(O)(=O)=O)=CC=1.O.C(Cl)(Cl)Cl.CO>CO>[Br:1][CH2:2][CH:3]([CH2:14][OH:15])[CH2:4][CH2:5][N:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][C:7]1=[O:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 21584188Chloroform methanolHCID 594637601-(3-Bromomethyl-4-trityloxybutyl)-1H-pyrimidine-2,4-dione

생성물 1

HCID 594637591-(3-Bromomethyl 4-hydroxybutyl)-1H-pyrimidine-2,4-dione

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of compound 37 (22 g, 0.042 mol) in methanol (100 mL) was treated with PTSA. H2O (0.80 g, 0.0042 mol) and stirred for 6 h at RT. The reaction mixture was concentrated under vacuum and the crude compound was used for next reaction (10.5 g, crude product). TLC: Chloroform/Methanol, 1:1, Rf=0.2

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customthe crude compound was used for next reaction (10.5 g, crude product)

출처 및 근거

ORD 기록
ord-a3cce3229e0f49e8a95f29a5ca01b777
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795270B2

반응 노트

불러오는 중…