Sodium Azide → 1-(3-Azidomethyl-4-hydroxybutyl)-1H-pyrimidine-2,4-dione

HRID 1713378노트

반응식

HRID 1713378 반응식
Br[CH2:2][CH:3]([CH2:14][OH:15])[CH2:4][CH2:5][N:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][C:7]1=[O:13].[N-:16]=[N+:17]=[N-:18].[Na+]>CN(C=O)C>[N:16]([CH2:2][CH:3]([CH2:14][OH:15])[CH2:4][CH2:5][N:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][C:7]1=[O:13])=[N+:17]=[N-:18]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 594637591-(3-Bromomethyl 4-hydroxybutyl)-1H-pyrimidine-2,4-dione

생성물 1

HCID 594637631-(3-Azidomethyl-4-hydroxybutyl)-1H-pyrimidine-2,4-dione수율 51.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

A solution of compound 38 (10.9 g, 0.042 mol) in dry DMF (40 mL) was treated with NaN3 (4.1 g, 0.062 mol) and heated to 70° C. for 24 h. The reaction mixture was concentrated under vacuum and crude purified by column chromatography over silica gel (30% methanol in chloroform) to give the title compound (5.2 g, 47%). TLC: Chloroform/Methanol, 1:1, Rf=0.2

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum and crude
  2. custompurified by column chromatography over silica gel (30% methanol in chloroform)

출처 및 근거

ORD 기록
ord-7982a509f2a245fb8e39c3ead38acc58
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795270B2

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