3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide → 6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

HRID 1713389노트

반응식

HRID 1713389 반응식
[CH3:1][N:2]([CH3:18])[S:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([N:12]=[CH:13][C:14]=2[C:15](Cl)=[O:16])[CH:11]=1)(=[O:5])=[O:4].[NH2:19][C:20]1[CH:21]=[C:22]([CH:36]=[CH:37][C:38]=1[CH3:39])[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=1)=[O:24]>N1C=CC=CC=1>[CH3:39][C:38]1[CH:37]=[CH:36][C:22]([C:23](=[O:24])[NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=2)=[CH:21][C:20]=1[NH:19][C:15]([C:14]1[CH:13]=[N:12][N:10]2[CH:11]=[C:6]([S:3](=[O:5])(=[O:4])[N:2]([CH3:18])[CH3:1])[CH:7]=[CH:8][C:9]=12)=[O:16]

참가 물질

4

반응물 2

HCID 201196943-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamideHCID 866251176-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride

생성물 1

HCID 166620846-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride (200 mg, 0.35 mmol) and 3-amino-4-methyl-N-(3-trifluoromethyl-phenyl)-benzamide are reacted in 2 ml dry pyridine at r.t. for 18 hrs. The solvent is removed under reduced pressure. The product is isolated by automated column chromatography and is dried at the high vacuum pump, yielding the title compound as a white solid.

후처리

  1. customThe solvent is removed under reduced pressure
  2. customThe product is isolated by automated column chromatography
  3. customis dried at the high vacuum pump

출처 및 근거

ORD 기록
ord-3ef696b5e4514f45914c00dc16067d8a
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795273B2

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