Pyridine → HCID 178500684, 화합물

HRID 1713796노트

반응식

HRID 1713796 반응식
Cl[C:2](=[O:7])[C:3]([O:5][CH3:6])=[O:4].[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C@H:15]2[CH2:20][CH2:19][C@H:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:17][CH2:16]2)=[CH:11][CH:10]=1.N1C=CC=CC=1>C(Cl)Cl>[CH3:25][O:24][C:22](=[O:23])[CH2:21][C@H:18]1[CH2:17][CH2:16][C@H:15]([C:12]2[CH:11]=[CH:10][C:9]([NH:8][C:2](=[O:7])[C:3]([O:5][CH3:6])=[O:4])=[CH:14][CH:13]=2)[CH2:20][CH2:19]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 79846Methyl chloroglyoxylateHCID 178500653HCID 178500653, 화합물

생성물 1

HCID 178500684HCID 178500684, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Methyl chloro(oxo)acetate (0.842 mL) was added to a stirred solution of methyl [trans-4-(4-aminophenyl)cyclohexyl]acetate (1740 mg) and pyridine (0.689 mL) in DCM (50 mL) at 0° C. After the addition was complete the mixture was allowed to warm to ambient temperature and stirred for 64 hours. The solution was diluted with DCM (100 mL), washed with water (50 mL) and brine (50 mL), then dried and concentrated in vacuo to give the title compound (2267 mg) as a solid; 1H NMR δ 7.60 (2H, d), 7.18 (2H, d), 3.83 (3H, s), 3.58 (3H, s), 2.58-35 (1H+DMSO, m), 2.21 (2H, d), 1.75 (5H, m), 1.43 (2H, m), 1.12 (2H, m); MS m/e MH− 332.

후처리

  1. additionAfter the addition
  2. washwashed with water (50 mL) and brine (50 mL)
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1889c2b9165441779f181ab59cfd58a7
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795283B2

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