Oxalyl chloride → HCID 11436518, 화합물

HRID 1714078

반응식

HRID 1714078 반응식
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][CH:6]([CH2:10][CH2:11][CH2:12][CH3:13])C(O)=O)=[O:4].C(Cl)(=O)[C:17]([Cl:19])=[O:18]>ClCCl.CN(C)C=O>[F:15][C:2]([F:1])([F:14])[C:3]([NH:5][CH2:6][CH2:10][CH2:11][CH2:12][CH2:13][C:17]([Cl:19])=[O:18])=[O:4]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 3035902-[(2,2,2-Trifluoroacetyl)amino]hexanoic acid

생성물 1

HCID 11436518HCID 11436518, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

735 mg(3 mmol) (2,2,2-trifluoro-acetylamino)-hexanoic acid were dissolved in 5 mL dried dichloromethane and stirred under argon flux at 0° C. Then, 0.6 mL (6.6 mmol) oxalyl chloride were added dropwise at 0° C., a few drops of dried dimethylformamide were also added dropwise which lead to gas development and yellow colouring of the previously white mixture. The mixture, was stirred at room temperature for 70 min. Then the mixture was repeatedly evaporated with dichloromethane. The crude product was used directly in the next step.

후처리

  1. stirringThe mixture, was stirred at room temperature for 70 min
  2. customThen the mixture was repeatedly evaporated with dichloromethane

출처 및 근거

ORD 기록
ord-b39c693e046641f98956833f6e0466d1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795423B2

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