참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 8-Iodo-3-(phenylsulfonyl)quinoline | HCID 11406774 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Bis(cyclopenta-2,4-dien-1-yl(phenyl)phosphane);iron(2+) | HCID 133083342 | — |
| 생성물 | 8-(4-Methyl-piperazin-1-yl)-3phenylsulfonylquinoline | HCID 9929162 | — |
반응 단계
8-Iodo-3-phenylsulfonyl-quinoline (D6) (190 mg, 0.48 mmol), N-methyl-piperazine (48 mg, 0.48 mmol), sodium tertbutoxide (65 mg, 0.68 mmol), di-palladium tetrakis-(dibenzylidine acetone) [Pd2(dba)3] (88 mg, 0.1 mmol) and 1,1′-diphenylphosphino ferrocene (161 mg, 0.3 mmol) were suspended in degassed dry dioxan (2 ml). The mixture was stirred under argon at 40° C. for 16 hours. The solvent was removed and the residue subjected to flash chromatography on silica gel (eluting with dichloromethane-methanol aq. ammonia) to give the title compound (E1), identical spectroscopically to that prepared by the earlier methods.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07799774B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_09 |
|---|
| ORD ID | ord-a30beed5802649d7baec50e4aea8984b |
|---|
| 출처 메모 | uspto-grants-2010_09 |
|---|
