Triethylamine → Tert-butyl [3-(4,4-dimethyl-1,3-oxazolidin-3-yl)-3-oxopropyl]carbamate

HRID 1715251

반응식

HRID 1715251 반응식
[CH3:1][C:2]1([CH3:7])[CH2:6][O:5][CH2:4][NH:3]1.[C:8]([NH:15][CH2:16][CH2:17][C:18](O)=[O:19])([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].C(N(CC)CC)C.[I-].ClC1C=CC=C[N+]=1C>C(Cl)Cl.C1CCCCC1.CCOC(C)=O>[CH3:1][C:2]1([CH3:7])[CH2:6][O:5][CH2:4][N:3]1[C:18](=[O:19])[CH2:17][CH2:16][NH:15][C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 620104,4-Dimethyl oxazolidineHCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanineHCID 1670692-Chloro-1-methylpyridinium iodide

생성물 1

HCID 86621990Tert-butyl [3-(4,4-dimethyl-1,3-oxazolidin-3-yl)-3-oxopropyl]carbamate수율 139.5%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 21867204Cyclohexane ethylacetate용매

실험 절차

To a mixture of 4,4-dimethyloxazolidine (287 μl; 2 mmol; 1 eq) and boc-beta-alanine (416.3 mg; 2.2 mmol; 1.10 eq) in DCM (30 ml), are added triethylamine (832 μl; 6 mmol; 3 eq) and 2-chloro-1-methylpyridinium iodide (1533 mg; 6 mmol; 3 eq). The mixture is stirred for 2 days at RT. The reaction is followed by TLC cyclohexane/EtOAc 1:1). The reaction mixture is then washed twice with NH4Cl sat. solution and twice with NaHCO3 sat. solution. The organic layer is dried over Na2SO4, filtered and concentrated to give 760 mg of an orange oil, which is purified by flash chromatography (cyclohexane/EtOAc gradient, from 9/1 to 1/1 over 30 min). The title product is isolated as a white-off solid (420.5 mg; 77%).

후처리

  1. washThe reaction mixture is then washed twice with NH4Cl sat. solution and twice with NaHCO3 sat. solution
  2. dry with materialThe organic layer is dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aebc291accbd4055ad19e939995446b1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07799814B2

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