Hydroxylamine → HCID 54592521, 화합물

HRID 1715260노트

반응식

HRID 1715260 반응식
[C:1]([CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])#[N:2].[NH2:13][OH:14]>CCO>[NH2:2]/[C:1](=[N:13]/[OH:14])/[CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10]

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 2735664tert-butyl N-(2-cyanoethyl)carbamate

생성물 1

HCID 54592521HCID 54592521, 화합물수율 99.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Tert-butyl N-(2-cyanoethyl)carbamate (40 g; 235 mmol; 1 eq.) and hydroxylamine (41.6 ml; 705 mmol; 3 eq.) are dissolved in EtOH (800 ml). The resulting solution is heated under reflux for 2 hours. The reaction progression is followed by 1H NMR. After 2 hours, the reaction mixture is cooled down to RT, concentrated under high vacuum to afford the title compound as a white solid (47.5 g, 99%).

후처리

  1. temperatureThe resulting solution is heated
  2. temperatureunder reflux for 2 hours
  3. concentrationconcentrated under high vacuum

출처 및 근거

ORD 기록
ord-5de7d2eb2a6f410a983d759a63b62271
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07799814B2

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