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Triethylamine → N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide

HRID 1715354
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HRID 1715354 반응식
F[C:2]([F:14])(F)[C:3]([C:5]1[S:9][C:8]([C:10]([OH:12])=O)=[CH:7][CH:6]=1)=[O:4].N=C=N.Cl.[NH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22].CCN(CC)CC>C(Cl)Cl>[O:22]=[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:20][NH:19][C:10]([C:8]1[S:9][C:5]([C:3](=[O:4])[CH2:2][F:14])=[CH:6][CH:7]=1)=[O:12]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 160435CarbodiimideHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)HCID 242747015-(2,2,2-Trifluoroacetyl)thiophene-2-carboxylic acid

생성물 1

HCID 86628838N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매
2회

실험 절차

To a solution of Example 1, A1 in DCM was added Pol-supported carbodiimide (2 eq) and the suspension was stirred at RT for 30 min. A solution of 2-aminoacetophenone HCl (1.1 eq) and Et3N (1.1 eq) in DCM was added and the resulting suspension was stirred at RT overnight. The resin was filtered, washed with DCM, and the filtrate was evaporated at reduced pressure. Purification by flash chromatography on silica gel eluting with DCM gave the title compound as a solid.

후처리

  1. stirringthe resulting suspension was stirred at RT overnight
  2. filtrationThe resin was filtered
  3. washwashed with DCM
  4. customthe filtrate was evaporated at reduced pressure
  5. customPurification by flash chromatography on silica gel eluting with DCM

출처 및 근거

ORD 기록
ord-8ee931b835914bd4a9f23d64613a623f
출처 데이터셋
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07799825B2

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