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N-methyl-2-pyrrolidone → 4-{[4-(4-Bromophenyl)pyrimidin-2-yl]amino}benzenesulfonamide

HRID 1715693
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HRID 1715693 반응식
CN([CH:4]=[CH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1)=O)C.[NH:15]([C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH2:28])(=[O:27])=[O:26])=[CH:21][CH:20]=1)[C:16]([NH2:18])=[NH:17].CN1C(=O)CCC1>O>[Br:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[CH:4][N:18]=[C:16]([NH:15][C:19]3[CH:24]=[CH:23][C:22]([S:25]([NH2:28])(=[O:26])=[O:27])=[CH:21][CH:20]=3)[N:17]=2)=[CH:9][CH:10]=1
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참가 물질

5

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 6172441-(4-Bromophenyl)-3-(dimethylamino)-2-propen-1-oneHCID 178512579HCID 178512579, 화합물

생성물 1

HCID 574467974-{[4-(4-Bromophenyl)pyrimidin-2-yl]amino}benzenesulfonamide수율 99.9%

시약·촉매·용매 1

HCID 962Water용매

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온도
120 °C

실험 절차

A flask is charged with the 1-(4-bromo-phenyl)-3-dimethylamino-propenone (1.05 g, 4.10 mmol), 4-guanidino-benzenesulfonamide (1.33 g, 6.20 mmol), and NMP (30 ml). The reaction mixture is stirred at 120° C. for 20 h. The reaction mixture is cooled to room temperature, diluted with water, and filtered. The solid residue is washed with water and dried to yield 1.66 g of a white solid. MS (ESI) m/z 405.1; HRMS: calcd for C16H13BrN4O2S+H+, 405.00153; found (ESI-FTMS, [M+H]1+), 405.00158.

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationfiltered
  3. washThe solid residue is washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-d4748d8351f64745925345778e099815
출처 데이터셋
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07799915B2

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