Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → Irbesartan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Irbesartan hydrochloride | HCID 11568906 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Irbesartan | HCID 3749 | — |
반응 단계
100 g of anhydrous irbesartan hydrochloride was taken in a mixture of 250 ml toluene and 250 ml water. The pH of the reaction mass was adjusted to 6.5 to 7.0 with aqueous ammonia at 25-30° C. and stirred for about 30 minutes and filtered. The product was dried at 60° C. under vacuum to yield Form A of irbesartan free base.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07799928B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-63630d540c32495c932d321ae0909986 |
| 출처 메모 | uspto-grants-2010_09 |