4-Methylpyridine → 2-Acetoxy-4-methylpyridine

반응식

[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.CC1C=CN=CC=1.F[O:17][C:18](=O)[CH3:19]>>[C:18]([O:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)(=[O:17])[CH3:19]

참가 물질

반응물 3

HCID 79634-Methylpyridine

HCID 127602Acetyl hypofluorite

HCID 178428601HCID 178428601, 화합물

생성물 1

HCID 122581882-Acetoxy-4-methylpyridine

실험 절차

As a process for the preparation of 2-hydroxy-4-methylpyridine, a process whereby [iv] 4-methylpyridine is reacted with acetyl hypofluorite at −10° C. to obtain a 2-acetoxy-4-methylpyridine, and thereafter the 2-acetoxy-4-methylpyridine is hydrolyzed to obtain 4-methyl-2-pyridone is reported [Journal of the American Chemical Society, 109, 3789-3790, (1987): Non-Patent Reference 2].

출처 및 근거

ORD 기록: ord-2e4a7a241e264fceae07206f948c3c7b
출처 데이터셋: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07803585B2

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