Quinuclidine → 1-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

HRID 1716199노트

반응식

HRID 1716199 반응식
[Br:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]=[S:7].[N:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2>C(#N)C>[Br-:1].[N:5]([CH2:4][CH2:3][CH2:2][N+:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2)=[C:6]=[S:7]

참가 물질

4

반응물 2

HCID 7527QuinuclidineHCID 1377143-Bromopropyl isothiocyanate

생성물 1

HCID 231542151-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
50 °C

실험 절차

To a solution of 55 mg of 3-bromopropyl isothiocyanate in 1 ml of acetonitrile was added 33 mg of quinuclidine, and the mixture was heated at 50° C. for 19 hours. The reaction solution was concentrated and the residue was washed 3 times with 1 ml of ether to obtain the title compound.

후처리

  1. concentrationThe reaction solution was concentrated
  2. washthe residue was washed 3 times with 1 ml of ether

출처 및 근거

ORD 기록
ord-5b978d1c31f64d4a8e4cfa3048bbf0e2
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803792B2

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