4-Fluorobenzenesulfonyl chloride → N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

HRID 1716281노트

반응식

HRID 1716281 반응식
[NH2:1][C:2]1[C:3]([Br:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>ClCCl.N1C=CC=CC=1>[Br:8][C:3]1[C:2]([NH:1][S:16]([C:13]2[CH:14]=[CH:15][C:10]([F:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 6428163-Amino-2-bromopyridine

생성물 1

HCID 86619934N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 3-amino-2-bromo-pyridine (0.4 g, 2.3 mmol) in dichloromethane (4 ml) and pyridine (4 ml) was added 4-fluoro-benzenesulfonylchloride (0.45 g, 2.3 mmol) in one portion. The mixture was stirred overnight. The mixture was diluted with dichloromethane and washed with saturated NaCl solution. The organic layer was dried over sodium sulfate and concentrated. The crude product was purified through chromatography (2-5% EtOAc in dichloromethane). MS 331.8 (M+H)+

후처리

  1. washwashed with saturated NaCl solution
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. customThe crude product was purified through chromatography (2-5% EtOAc in dichloromethane)

출처 및 근거

ORD 기록
ord-7835a80f5e544a4eaccc53c5708fcdb0
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803793B2

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