3-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one → 3-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

HRID 1716306노트

반응식

HRID 1716306 반응식
C([O:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CS(O)(=O)=O>[OH:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1

참가 물질

3

반응물 1

HCID 685103983-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one

생성물 1

HCID 444558373-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

시약·촉매·용매 1

HCID 6395Methanesulfonic Acid용매

실험 절차

A solution of 3-benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one (50 mg) from Step B in MeSO3H (1.5 mL) was stirred at room temperature for 20 min and then quenched with ice water. The solid was filtered off and washed with water. The crude product was re-dissolved in hot MeOH (1 mL) and removed un-dissolved brownish solid. The filtrate was concentrated in vacuo to give the titled compound. MS (EI) 280 (M+H)+.

후처리

  1. customquenched with ice water
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. dissolutionThe crude product was re-dissolved in hot MeOH (1 mL)
  5. customremoved
  6. dissolutionun-dissolved brownish solid
  7. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-769f85478d454fe49c95ee592e78da34
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803793B2

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