HCID 68509534, 화합물 → 1,1-Dimethylethyl 4-[(2-amino-4-methylphenyl)amino]-1-piperidinecarboxylate

HRID 1716560노트

반응식

HRID 1716560 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[N+:22]([O-])=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[NH2:22])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 68509534HCID 68509534, 화합물

생성물 1

HCID 588522881,1-Dimethylethyl 4-[(2-amino-4-methylphenyl)amino]-1-piperidinecarboxylate수율 90.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 4-(4-methyl-2-nitro-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (9.5 g, 28.4 mmol) in ethanol (150 mL) was added 10% Pd/C (125 mg) and the reaction mixture was shaken under H2 (50 psi) at rt for 1 h. The catalyst was then removed by filtration through a pad of Celite® and washed with ethanol. The filtrate was concentrated in vacuo to provide 4-(2-amino-4-methyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (7.83 g) in 90% yield.

후처리

  1. customThe catalyst was then removed by filtration through a pad of Celite®
  2. washwashed with ethanol
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-fc9efd3eb23a46cfb00f0a537f66af38
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803816B2

반응 노트

불러오는 중…