3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester → 6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile
반응식
C([O:3][C:4](=O)[CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)C.OCCC(C1C=CC=C2C=1C(C#N)=CN2)C1C=CC=CC=1>>[OH:3][CH2:4][CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1참가 물질
3
실험 절차
6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile CLXXII was prepared from 3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester using the procedure described for preparation of 4-(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LX (Example 14).
출처 및 근거
- ORD 기록
- ord-247b0d6e23eb45099521636cebbd44ae
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07803830B2
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