4-Fluoro-3-nitroaniline → 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide

HRID 1716886

반응식

HRID 1716886 반응식
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F:12][C:13]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:14]=1[C:15](Cl)=[O:16]>O1CCOCC1>[F:12][C:13]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:14]=1[C:15]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([F:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)=[O:16]

참가 물질

4

반응물 2

HCID 677684-Fluoro-3-nitroanilineHCID 5880812,4-Difluorobenzoyl chloride

생성물 1

HCID 92126042,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide수율 84.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Using a method similar to Preparation 13, using 4-fluoro-3-nitroaniline (1.0 g, 6.4 mmol), dioxane (20 mL), and 2,4-difluorobenzoyl chloride (1.46 g, 8.3 mmol) gives the title intermediate (1.6 g, 84% yield): mass spectrum (ion spray): m/z=297.0 (M+1).

후처리

  1. customsimilar to Preparation 13

출처 및 근거

ORD 기록
ord-7251dd4e57124d51a15543d798e79f03
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803813B2

연결된 노트

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