Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Diaminopyridine → N-(6-Aminopyridin-2-yl)-2,6-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Diaminopyridine | HCID 8861 | — |
| 반응물 | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-(6-Aminopyridin-2-yl)-2,6-difluorobenzamide | HCID 44203136 | 75.2% |
반응 단계
Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 24 mmol), dioxane (75 mL), and 2,6-difluorobenzoyl chloride (1.4 g, 8 mmol) (stir at 25° C. for 16 hr.), gives the title intermediate (1.5 g, 75% yield): mass spectrum (ion spray): m/z=250.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07803813B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-c3450ad10e3e4933af2f17642f4527ed |
| 출처 메모 | uspto-grants-2010_09 |