Azido(trimethyl)stannane → HCID 178522031, 화합물

반응식

[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[O:14][C:15]([Br:18])=[CH:16][CH:17]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2].[Sn]([N:23]=[N+:24]=[N-:25])(C)(C)C>>[NH:23]1[C:1]([CH2:3][C:4]2[CH:5]=[C:6]([NH:10][C:11]([C:13]3[O:14][C:15]([Br:18])=[CH:16][CH:17]=3)=[O:12])[CH:7]=[CH:8][CH:9]=2)=[N:2][N:25]=[N:24]1

참가 물질

반응물 2

HCID 5104973Azido(trimethyl)stannane

HCID 596548595-Bromo-furan-2-carboxylic acid (3-cyanomethyl-phenyl)-amide

생성물 1

HCID 178522031HCID 178522031, 화합물

실험 절차

Nitrile (83) (162 mg, 0.53 mmol) was treated with Me3SnN3 using Method K. The residue was purified by column chromatography, flushing with heptane (200 ml) and eluting with 50% EtOAc in heptane to give the title compound.

후처리

customThe residue was purified by column chromatography
customflushing with heptane (200 ml)
washeluting with 50% EtOAc in heptane

출처 및 근거

ORD 기록: ord-d984b7d3efdd4c2c938e3809bf181386
출처 데이터셋: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07803841B2

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