Ethyl 2-(3-aminophenoxy)acetate → [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

HRID 1717133

반응식

HRID 1717133 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH2:12]([O:14][C:15](=[O:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[F:11])[CH:19]=1)[CH3:13]

참가 물질

3

반응물 2

HCID 412308Ethyl 2-(3-aminophenoxy)acetateHCID 27363155-Bromo-2-fluorobenzoic acid

생성물 1

HCID 40356283[3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

실험 절차

5-Bromo-2-fluoro-benzoic acid (250 mg, 1.14 mmol) was coupled to aniline (64) (245 mg, 1.25 mmol) using Method D. The residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.

후처리

  1. customThe residue was purified by column chromatography
  2. washeluting with a stepped gradient of 10-15% EtOAc in heptane

출처 및 근거

ORD 기록
ord-249a52a65e70453fa851bc1a3611b54c
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803841B2

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