Ethyl 2-(3-aminophenoxy)acetate → (3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

HRID 1717148

반응식

HRID 1717148 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:16]([O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][C:13]([C:11]2[O:12][C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)=[O:15])[CH:23]=1)[CH3:17]

참가 물질

3

반응물 2

HCID 412308Ethyl 2-(3-aminophenoxy)acetateHCID 7389915-(4-Fluorophenyl)furan-2-carboxylic acid

생성물 1

HCID 39268564(3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

실험 절차

Carboxylic acid (76) (53 mg, 0.26 mmol) was coupled to aniline (64) (56 mg, 0.26 mmol) using Method C to give the title compound.

출처 및 근거

ORD 기록
ord-d4aedb6a753142c883ce1f9d482901c1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803841B2

연결된 노트

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