Ethyl Bromide → 3-ethoxy-N-ethyl-4-nitrobenzamide

HRID 1717328노트

반응식

HRID 1717328 반응식
[CH2:1]([NH:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([OH:14])[CH:6]=1)[CH3:2].[CH2:16](Br)[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:16]([O:14][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[N+:11]([O-:13])=[O:12])[C:4]([NH:3][CH2:1][CH3:2])=[O:15])[CH3:17]

참가 물질

5

반응물 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 21029708N-ethyl-3-hydroxy-4-nitrobenzamide

생성물 1

HCID 685151263-ethoxy-N-ethyl-4-nitrobenzamide수율 30%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of N-ethyl-3-hydroxy-4-nitrobenzamide (2.10 g) obtained in Example 131a) in acetone (100 ml) were added ethyl bromide (0.75 ml) and potassium carbonate (1.38 g), and the reaction mixture was heated under reflux overnight. The reaction mixture was allowed to cool to room temperature and the solvent was evaporated under reduced pressure. Ethyl acetate and water were added to the residue. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a pale-brown solid (0.72 g, 30%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux overnight
  3. customthe solvent was evaporated under reduced pressure
  4. additionEthyl acetate and water were added to the residue
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9ead7259b1fd45b5bfccfd41b0cf1cd1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803822B2

반응 노트

불러오는 중…