Methanol → Methyl 2-(bromomethyl)-6-methylbenzoate

HRID 1717442

반응식

HRID 1717442 반응식
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5](Br)=[O:6].[CH3:13][OH:14]>CCCCCCC>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5]([O:14][CH3:13])=[O:6]

참가 물질

4

반응물 2

HCID 887MethanolHCID 219803072-(Bromomethyl)-6-methylbenzoyl bromide

생성물 1

HCID 10263795Methyl 2-(bromomethyl)-6-methylbenzoate수율 98.8%

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

200 g (240 mmol) of 2-bromomethyl-6-methylbenzoyl bromide solution (35% solution in heptane) are added to 400 ml of methanol. After stirring at RT for one hour, 400 ml of n-heptane are added. The solution is washed successively with 600 ml of sat. sodium hydrogencarbonate solution and three times with 200 ml each time of water. Subsequently, the solvent is removed fully under reduced pressure. 98.8% of methyl 2-bromomethyl-6-methylbenzoate is obtained as a colorless oil having a purity of 80% (included in the yield) and having a molecular weight of 241.99 (C10H11BrO2); MS (ESI): 243.1 [M+H+].

후처리

  1. washThe solution is washed successively with 600 ml of sat. sodium hydrogencarbonate solution and three times with 200 ml each time of water
  2. customSubsequently, the solvent is removed fully under reduced pressure

출처 및 근거

ORD 기록
ord-a454f6bc4218401bb442a2697f33111c
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803950B2

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