2-Nitro-5-(trifluoromethoxy)benzoic acid → 2-amino-5-(trifluoromethoxy)benzoic Acid

HRID 1717457

반응식

HRID 1717457 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:15])([F:16])[F:17])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 1

HCID 219046132-Nitro-5-(trifluoromethoxy)benzoic acid

생성물 1

HCID 110853492-amino-5-(trifluoromethoxy)benzoic Acid수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 2-nitro-5-trifluoromethoxybenzoic acid (56.8 g, 0.23 mol; see step (i) above) in EtOH (1000 mL) was added 10% Pd/C (5.7 g). The resulting solution was flushed with H2 for 5 h, filtered through Celite® and concentrated in vacuo to give the crude sub-title compound (49.7 g, 98%) as a solid that was used in the next step without further purification.

후처리

  1. customThe resulting solution was flushed with H2 for 5 h
  2. filtrationfiltered through Celite®
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-119c922b6c4a4fcdb1adef22e767e7a2
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803954B2

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