3-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrile → 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-methoxy-methyl}-benzonitrile

HRID 1717762

반응식

HRID 1717762 반응식
[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([CH:16]([O:25][CH:26]3CCCCO3)[C:17]3[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=3)[C:20]#[N:21])=[CH:12][CH:11]=2)=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[OH:37])(=[O:3])[CH3:2].OCC1C=CC(C(OC)C2C=C(C=CC=2)C#N)=CC=1>>[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([CH:16]([O:25][CH3:26])[C:17]3[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=3)[C:20]#[N:21])=[CH:14][CH:15]=2)=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[OH:37])(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 574383533-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrileHCID 666996043-[[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-benzonitrile

생성물 1

HCID 666995583-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-methoxy-methyl}-benzonitrile

실험 절차

The title compound is prepared in a similar manner to 3-[[4-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-benzonitrile employing 3-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrile to afford 248 mg, 78%, as a colorless oil. LCMS M+1 430.

후처리

  1. customto afford 248 mg, 78%

출처 및 근거

ORD 기록
ord-c82cd37b7bfd496c8b984fd937f38586
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803938B2

연결된 노트

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