1-(Bromomethyl)-2,3-difluoro-benzene → Ethyl 2-(2,3-difluorobenzyl)-3-oxobutyrate

HRID 1718826노트

반응식

HRID 1718826 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:4]=1[F:10].[Na].[C:12]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15]>O1CCCC1>[F:10][C:4]1[C:5]([F:9])=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][CH:13]([C:14](=[O:15])[CH3:16])[C:12]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

4

반응물 2

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 87089461Ethyl acetoacetatesodium salt

생성물 1

HCID 57460769Ethyl 2-(2,3-difluorobenzyl)-3-oxobutyrate수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1-(bromomethyl)-2,3-difluorobenzene (1.6 g) and ethyl acetoacetate sodium salt (2.36 g) in tetrahydrofuran (20 mL) was stirred for 12 hr. The insoluble material was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (1.56 g, 79%) as a colorless viscous oil.

후처리

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-7aac95f8b16644ff9420b1eaeb712a43
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803940B2

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