Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Oxoadipic acid → Z-2-(2,2-Dimethylcyclopropanecarboxamido)-2-hexenedioic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Oxoadipic acid | HCID 71 | — |
| 반응물 | Methyl isovalerate | HCID 11160 | — |
| 반응물 | 2,2-Dimethylcyclopropanecarboxamide | HCID 574717 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Z-2-(2,2-Dimethylcyclopropanecarboxamido)-2-hexenedioic acid | HCID 13505568 | — |
반응 단계
A mixture of 1.0 g. of 2,2-dimethylcyclopropanecarboxamide, 2.4 g. of 2-ketoadipic acid and 25 ml. of methyl isovalerate was heated under reflux for 4 hrs, with removal of H2O by a modified Dean-Stark trap containing molecular sieves (4A). After standing at room temperature overnight, the crystalline precipitate was filtered, washed with ether and recrystallized from ethyl acetate to give 0.23 g. of product, m.p. 163°-165°. The NMR spectrum was consistent with the desired structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04539208 |
| 출처 데이터셋 | uspto-grants-1985_09 |
| ORD ID | ord-ac5ad055393b4134ab747db883fd05e0 |
| 출처 메모 | uspto-grants-1985_09 |