HCID 13251296, 화합물 → 3,4-Dichlorobenzyl chloride

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5]N1C2C(=CC=CC=2C(F)(F)F)C2(C(=O)NC(=O)N2)C1=O.[Cl:30]C1C=C(C=CC=1Cl)C[N:35]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][C:42]=2[C:44]([F:47])([F:46])[F:45])[C:37](=[O:48])[C:36]1=[O:49]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][Cl:30].[F:47][C:44]([F:45])([F:46])[C:42]1[CH:41]=[CH:40][CH:39]=[C:38]2[C:43]=1[NH:35][C:36](=[O:49])[C:37]2=[O:48]

참가 물질

반응물 2

HCID 13251296HCID 13251296, 화합물

HCID 202680181-[(3,4-Dichlorophenyl)methyl]-7-(trifluoromethyl)-1H-indole-2,3-dione

생성물 2

HCID 76093,4-Dichlorobenzyl chloride

HCID 6045757-Trifluoromethylisatin

실험 절차

(Example 4): 1'-(3,4-dichlorobenzyl)-7'-trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione, as a solid m.p. 170°-171° C., starting from 1-(3,4-dichlorobenzyl)-7-trifluoromethylindoline-2,3-dione (itself obtained as a syrup of satisfactory purity by NMR, by reaction of 3,4-dichlorobenzyl chloride with 7-trifluoromethylindoline-2,3-dione in an analogous manner to that described for the starting material in Example 1);