5-Chloropyrimidin-2-ol hydrochloride → 5-Chloro-1-{[(thiophen-2-yl)methoxy]methyl}pyrimidin-2(1H)-one
반응식
Cl[CH2:2][O:3][CH2:4][C:5]1[S:6][CH:7]=[CH:8][CH:9]=1.Cl.[Cl:11][C:12]1[CH:13]=[N:14][C:15](=[O:18])[NH:16][CH:17]=1>>[C:5]1([CH2:4][O:3][CH2:2][N:16]2[CH:17]=[C:12]([Cl:11])[CH:13]=[N:14][C:15]2=[O:18])[S:6][CH:7]=[CH:8][CH:9]=1참가 물질
3
실험 절차
was prepared as described in Example 3 from 2-(chloromethyloxymethyl)thiophene (see Preparation 8a and 8b) (10 mmol) and 5-chloropyrimidin-2-one hydrochloride (10 mmol) in 57%. yield (1.45 g), m.p. 132° C. 1H NMR (CDCl3): δ4.80 (CH2Thioph.), 5.28 (CH2O), 6.7-7.2 (3H-Thioph.), 7.63 and 8.35 (H-4, H-6, J 4 Hz). IR(KBr): 1660 cm-1 (CO).
후처리
- customwas prepared
- customyield (1.45 g), m.p. 132° C
출처 및 근거
- ORD 기록
- ord-8c1aadde65204432bc725747f675b087
- 출처 데이터셋
- uspto-grants-1985_09
- 특허 번호
- US04539324
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