Thionyl Chloride → 1-(6-Chlorohexyl)-3-methyl-2-(1-imidazolyl)indole

HRID 1719400노트

반응식

HRID 1719400 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([CH3:21])=[C:13]1[N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1.C(=O)(O)[O-].[Na+]>>[Cl:3][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([CH3:21])=[C:13]1[N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1

참가 물질

4

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 202681751-(6-Hydroxyhexyl)-3-methyl-2-(1-imidazolyl)indole

생성물 1

HCID 202681921-(6-Chlorohexyl)-3-methyl-2-(1-imidazolyl)indole

실험 절차

Thionyl chloride (0.36 ml) is combined with 1-(6-hydroxyhexyl)-3-methyl-2-(1-imidazolyl)indole (1.3 g) at 0°. The mixture is then stirred at room temperature for 1 hour. Saturated aqueous sodium bicarbonate is added and the mixture is extracted with dichloromethane. The extract is washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Concentration to dryness and purification by chromatography gives 1-(6-chlorohexyl)-3-methyl-2-(1-imidazolyl)indole.

후처리

  1. extractionthe mixture is extracted with dichloromethane
  2. washThe extract is washed with saturated sodium chloride solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationConcentration
  5. customto dryness and purification by chromatography

출처 및 근거

ORD 기록
ord-322df61102c04e409372e62941e69904
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04539410

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