methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide → HCID 178481148, 화합물

HRID 1719506노트

반응식

HRID 1719506 반응식
[OH:1][C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:13])(=[O:12])[N:4]([CH3:14])[C:3]=1[C:15]([O:17]C)=O.[NH2:19][C:20]1[C:21](=[O:28])[C:22]([OH:27])=[CH:23][CH:24]=[CH:25][CH:26]=1>C1(C)C(C)=CC=CC=1>[OH:1][C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:12])(=[O:13])[N:4]([CH3:14])[C:3]=1[C:15]([NH:19][C:20]1[C:21](=[O:28])[C:22]([OH:27])=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:17]

참가 물질

4

반응물 2

HCID 54676532methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxideHCID 178507571HCID 178507571, 화합물

생성물 1

HCID 178481148HCID 178481148, 화합물수율 90.4%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A mixture of methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (2.95 g) and 2-amino-7-hydroxy-2,4,6-cycloheptatrien-1-one (1.5 g) in xylene (103 ml) was refluxed for 52 hours. The reaction mixture was cooled to room temperature. The crystals were collected by filtration and washed successively with N,N-dimethylformamide and chloroform to give 4-hydroxy-N-(7-hydroxy-1-oxo-2,4,6-cycloheptatrien-2-yl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (3.7 g).

후처리

  1. temperaturewas refluxed for 52 hours
  2. filtrationThe crystals were collected by filtration
  3. washwashed successively with N,N-dimethylformamide and chloroform

출처 및 근거

ORD 기록
ord-f88f88313e9d4841aeb4886ac77e1894
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04540692

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