5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → 2-[2-(2-Dimethylaminomethyl-5-furylmethylthio)ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one

HRID 1719543노트

반응식

HRID 1719543 반응식
[CH3:1][N:2]([CH2:4][C:5]1[O:6][C:7]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:8][CH:9]=1)[CH3:3].[N+](N[C:19]1[NH:24][C:23](=[O:25])[C:22]([CH2:26][C:27]2[CH:32]=[CH:31][N:30]([CH2:33][CH2:34][CH2:35][CH3:36])[C:29](=[O:37])[CH:28]=2)=[CH:21][N:20]=1)([O-])=O>N1C=CC=CC=1>[CH3:3][N:2]([CH2:4][C:5]1[O:6][C:7]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:19]2[NH:24][C:23](=[O:25])[C:22]([CH2:26][C:27]3[CH:32]=[CH:31][N:30]([CH2:33][CH2:34][CH2:35][CH3:36])[C:29](=[O:37])[CH:28]=3)=[CH:21][N:20]=2)=[CH:8][CH:9]=1)[CH3:1]

참가 물질

4

반응물 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 184701322-Nitroamino-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one

생성물 1

HCID 536530852-[2-(2-Dimethylaminomethyl-5-furylmethylthio)ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-(2-Dimethylaminomethyl-5-furylmethylthio)ethylamine (1.44 g) and 2-nitroamino-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one (1.76 g) were refluxed in pyridine (10 ml) for 24 hours. The reaction mixture was evaporated under reduced pressure to afford an oil which was washed with hot water. The mixture was allowed to cool overnight and the water was decanted to give the title compound as a residue. Ethanolic HCl (3 ml) and isopropanol were added with warming to give a solution which was evaporated under reduced pressure to give a residue which was recrystallised from isopropanolethanolic HCl to give 2-[2-(2-dimethylaminomethyl-5-furylmethylthio)ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one as a trihydrochloride salt (2.67 g), m.p. 169°-171.5° C.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customto afford an oil which
  3. washwas washed with hot water
  4. temperatureto cool overnight
  5. customthe water was decanted

출처 및 근거

ORD 기록
ord-f2246d7718324c38be6380e1be2089dd
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04540699

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