Fumarate → bromomesaconic acid

HRID 1719789노트

반응식

HRID 1719789 반응식
[Br:1][CH2:2]/[C:3](=[CH:7]/[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5].C([O-])(=O)/C=C/C([O-])=O.BrCC1C(OC(=O)C=1)=O>>[Br:1][CH2:2]/[C:3](=[CH:7]\[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 3

HCID 5460307FumarateHCID 109870762,5-Furandione, 3-(bromomethyl)-HCID 86740308HCID 86740308, 화합물2회

생성물 1

HCID 6449799bromomesaconic acid

실험 절차

Steps are taken to avoid isomerization of 2-(bromomethyl)-maleic acid (3) to the corresponding fumarate analog by hydrolyzing the anhydride (2) in a dilute aqueous solution and neutralizing the diacid (3) immediately after complete hydrolysis. Any bromomethyl fumaric acid derivative formed is removed in purifying compound (4) as described in more detail below.

후처리

  1. customimmediately after complete hydrolysis

출처 및 근거

ORD 기록
ord-43639ec7cebd449e9e16cfeaedc3e4fd
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04542225

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